Tag: ivf specialist in indore

Failed IVF: Not an end to life

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The need for IVF comes when a couple is having trouble to have baby, and then failure of IVF becomes another cause for disappointment. It is not easy to accept that you cannot have a baby after all the possible efforts. But this is not the end to possibilities. The first failed IVF cycle provide us with the information to make the next IVF treatment successful. Several issues seen in a previously unsuccessful IVF attempt may be addressed to eliminate or reduce the possibility of a single issue occurring in a second attempt with IVF.

There is a lot of grief and pain, most of the people start blaming one another. Was the doctor negligent or simply incompetent? Or has the patient neglected the health instructions given to him/ her? The reality is that we can understand a lot by a failed cycle. It is therefore important to generate a process, and to evaluate the redundant IVF cycle for improvement of the success rate in subsequent effort.

Give yourself time and allow grieving:

The heartbreaking news of the failing of your IVF cycle is quite disappointing. It is okay and natural to feel that way. It is necessary to take time to deal with the hurt caused to you; otherwise the feelings of depression will not go away.

Keep yourself away from the blame-game:

It is obvious that after a failed cycle of IVF one can expect some degree of anger and anxiety, let it fade away, or it can be disastrous. You need to understand the actual reason of failure of the cycle. And avoid any thoughts of blaming each other.  Usually the patient starts blaming God for their distressed situation but it also will not help. You need to keep yourself very much away from such blame-games.

Consultation with experts:

Consultation with a fertility specialist can be extremely beneficial. Many people gain a lot of strength by attending counselling sessions with fertility experts or family counsellors. As low as you may feel there is always a ray of hope.

Get focused on your follow-ups with the fertility specialists:

Whenever you feel that you are ready, you should make appointment with fertility specialist to review the cycle. Get all your doubts about the success rate, failure chances about second IVF effort and understand the differences. Avoid making any decisions until you take follow-up with your doctor. By this you will be able to understand the required changes that are needed to incorporate into the protocol to help you in later cycle. Your doctor may suggests some new techniques and few more fertility screening to be get done.

Apply changes to your lifestyle:

New fertile lifestyle activates your brain for the new and better strategies that are being introduced to the body, so it can expect better results. These changes can be as quitting alcohol and smoking, exercising, Weight management, healthy diet, etc.

Take care of your relationship:

As with any painful trauma, an unsuccessful IVF cycle put a lot of grief and depression in your mind and can interfere with your relationship. For some couples, the relationship itself may be less important than the goal of having a child. Remember to support your relationship with your partner, spend more time together and understand each other’s pain. The love between you as couple is very important to nurture a new life as parent.

Are you looking at the Best Hospital for Infertility Treatment in Indore, India? Mohak infertility center: We provide the IUI, IVF, ICSI treatment, Infertility Treatment and test tube baby treatment in India within your budget. Contact us for the right guidance about Infertility treatment and IVF Treatment. More information Call us 78980-47572 / 80852-77666 online visit – https://www.mohakivf.com

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To More Post: Sperm quality improve by frequent ejaculation rather than abstinence

Sperm quality improve by frequent ejaculation rather than abstinence

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“Do we need to update IVF protocols to use semen from shorter periods of abstinence?”

Introduction: Men have usually been advised to limit sexual activity to increase the chances of pregnancy. A new study suggests sperm quality and pregnancy outcomes in IVF may be improved with frequent ejaculation.

Summary: Research carried out Da Li et aVaimed to determine the effects of a short period of abstinence on the quality of ejaculated sperm, as well as its effect on the pregnancy outcomes of 500 couples undergoing EVE Major molecular differences were seen between samples of semen depending on the duration of abstinence. Ejaculates from short (1-3 hours) compared with long (3-7 days) periods of abstinence showed increases in motile sperm count, sperm vitality, normal sperm morphology, acrosome reaction  capacity,  total antioxidant  capacity,  sperm  mitochondria’  membrane  potential,  high  DNA stainability and a decrease in the sperm DNA fragmentation index (P<0.05). Sperm proteomic analysis showed 322 differentially expressed proteins (minimal fold change of ±1.5 or greater and P < 0.05), with 224 up-regulated and 98 down-regulated. These differentially expressed proteins are profoundly involved in specific cellular processes,  such as  motility and capacitation, oxidative stress and metabolism. Interestingly, protein trimethyllysine modification was increased and butyryllysine, propionyllysine and malonyllysine modifications were decreased in ejaculates from a short versus long abstinence (P < 0.051 Finally, the rates of implantation, clinical pregnancy and live births from in vitro fertilization treatments were significantly increased (by one-third in this study) in semen samples after a short abstinence. This study provides preliminary mechanistic insights into improved sperm quality and pregnancy outcomes associated with spermatozoa retrieved after a short ejaculatory abstinence.

Conclusion: These results collectively suggest that having more frequent sex produces sperm of a better quality and increases the likelihood of a successful pregnancy. Specifically, semen samples collected after only one to three hours of abstinence contained more motile sperm with a higher reproductive potential than samples collected after men who had abstained for three to seven days.

References*: Zi-Qi Shen, Bei Shi, Tian-Ren Wang, Liao Liao, Xuejun Shang, Qi-fun Wu, Yi-Ming Zhou, Tie-Feng Can, Qiang Du, Xiu-Xia Wang and Da Li. Characterization of the Sperm Proteome and Reproductive Outcomes with in Vitro Fertilization after a Reduction in Male Ejaculatory Abstinence Period. Molecular & Cellular Protearnics August 20, 2018, mcp.RA117.000541; https://doi.org/10.1074/mep.RA11 2000541

Source:  https://www.indianfertilitysociety.org/fertility-news-october-2018-volume-3/

If you are suffering from infertility problems and looking out for the Best IVF Center in Indore, India then there is no better place for you than Mohak infertility center. We deliver all the infertility treatment for men and woman at an affordable cost with the assured outcome. To book an appointment with the best IVF specialist at the best IVF center in MP, Indore, Call- 78980-47572 / 80852-77666 and online visit –https://www.mohakivf.com

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To More Post: FET may be more vulnerable to a suboptimal environment

Cochrane Review Series

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Question: Are ovarian stimulation protocols combining oral medications like Clomiphene citrate or Letrozole with gonadotropins effective and safe compared to gonadotropins alone in women undergoing In-vitro fertilization (IVF)?

Focus: Regimens using oral ovulogens and gonadotropins versus gonadotropins alone for women undergoing IVF.
Population Of Interest: Unselected IVF population of subfertile women undergoing controlled ovarian stimulation for IVF and ‘poor’ responders
Intervention Under Investigation: Clomiphene citrate (CC) or Letrozole (Ltz) with gonadotropins for controlled ovarian hyperstimulation (COH).
What Was The Comparison? : Gonadotropins alone for COH
What Were The Main Outcomes?: Live birth rate (LBR), ovarian hyperstimulation syndrome (OHSS) rate and cycle cancellation rate.

Results In Short: 

  • Twenty-two trials including 3599 women undergoing IVF.
  • Live birth rate: No difference in live birth rate following ovarian stimulation with CC or Ltz with gonadotropins versus gonadotropins alone (Risk Ratio (RR) 0.92, 95% confidence interval (CI) 0.66 to 1.27; 4 RCTs, 493 women, low-quality evidence) in the general IVF population1. No difference in live birth rate following ovarian stimulation with CC or Ltz and gonadotropins versus gonadotropins alone (RR 1.16, 95% CI 0.49 to 2.79, 2 RCTs, 357 women, low-quality evidence) among poor responders.
  • OHSS rate: Significantly lower incidence of OHSS following stimulation protocols using CC or Ltz with gonadotropins versus gonadotropins alone (Peto OR 0.21, 95% CI 0.11 to 0.41, 5 RCTs, 1067 women, low-quality evidence) in the general IVF population.
  • Cycle cancellation rate: Significantly higher cycle cancellation rate with CC or Ltz and gonadotropins versus gonadotropins alone (RR 1.87, 95% CI 1.43 to 2.45, 9 RCTs, 1784 women, low-quality evidence) in the general IVF population.
  • Number of gonadotropin ampoules and number of oocytes retrieved: Decrease in number of gonadotropin ampoules used and mean number of oocytes collected when CC or Ltz with gonadotropins was used compared with gonadotropin-only regimens (moderate quality evidence) in the general IVF population and poor responders.

Limitation: 

  • Only six among 22 included studiesreported live birth rates as primary outcome, necessitating cautious interpretation of overall results.
  • Studies included only fresh stimulated IVF cycles. None of the trials addressed surplus frozen embryos available for subsequent transfer; thereby data for cumulative live birth was not available. Currently, cumulative live birth rate is a more preferred outcome to evaluate effectiveness of IVF treatment.
  • Studies that assessed poor responders used varied criteria for inclusion thereby introducing clinical heterogeneity.
  • Lack of blinding in most included trials, poor reporting of methodology, differences in protocol and cycle cancellation policy impacted the overall quality of evidence.

Evidence Based Practice Points

  • Current weight of evidence suggests comparable live birth rates between CC or Ltz and gonadotropins versus gonadotropins alone,in both the routine IVF population and among poor responders. It is a viable alternative protocol in certain clinical scenarios like poor responders.
  • Addition of CC or Ltz reduces gonadotrophin requirement and incidence of ovarian hyperstimulation syndrome. Reduced gonadotrophin requirement could reduce initial treatment cost.
  • Higher cancellation rates and lower oocyte yield following use of CC or Ltz with gonadotrophin is a drawback. Cancellation of cycles can be psychologically distressing for the couples.
  • There has been a shift of contemporary practice towards maximizing oocyte yield in single retrieval cycle and “freeze all policy” due to higher cumulative live birth rate2. In light of these developments, studies evaluating cumulative live birth following milder stimulation protocols using CC or Ltz with gonadotrophins are needed along with cost effectiveness in order to establish their role in current IVF practice.

Reference: 
1.Kamath MS, Maheshwari A, Bhattacharya S, Lor KY, Gibreel A. Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation. Cochrane Database Syst Rev. 2017;11(11):CD008528.

2. Drakopoulos P, Blockeel C, Stoop D, Camus M, De Vos M, Tournaye H, Polyzos NP. Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize?

Source: https://www.indianfertilitysociety.org/ifs-catalyst-cochrane-vol-6/

Book an Appointment with Dr. Shilpa Bhandari Best Famous ivf specialist in indore at Mohak infertility center. Contact the Dr. Shilpa Bhandari best IVF, ICSI treatment, IUI treatment, test tube baby treatment, Laparoscopic surgery and infertility treatment in indore Provides. For More information Call us  78980-47572 / 80852-77666 online visit – https://www.mohakivf.com

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To More Post: Sleep disturbances may be associated with impaired fertility


Sleep disturbances may be associated with impaired fertility

Mohak infertility center

 “Should we be checking on sleep pattern for fertility assessment ?”

INTRODUCTION: Poor sleep health is a risk factor for a host of adverse health outcomes including obesity, type 2 diabetes, cardiovascular disease, depression and all-cause mortality. In reproductive epidemiology disrupted sleep patterns have been linked to a higher risk of adverse pregnancy outcomes such as gestational diabetes, stillbirth, preterm birth and low birth weight. New evidence has emerged that sleep disturbances may be associated with impaired fertility in women. Wise LA et al.1 reported short sleep duration in men was associated with reduced fecundability. Identifying modifiable determinants of infertility could provide alternatives to expensive fertility workups and treatments.

Rotten start to the day – Relationship Issues

SUMMARY: Gaskins AJ2 recently (2019) found association between short sleep duration (e.g., sleeping <6 hours compared with sleeping 8 hours) and lower fecundability, a fairly robust relationship between troubled sleep and lower fecundability. The cumulative probability of pregnancy at 12 months was 64% for women with trouble in sleeping more than 50% of the time compared with 76% among women with no trouble in sleeping. However, this association was largely attenuated with additional adjustment for male partner sleep duration and when restricted to nulliparous women. 20% of women in this cohort reported troubled sleep more than 50% of the time, so not a rare exposure. According to this study, women who had troubled sleep more than 50% of the time were of lower socioeconomic status, were more likely to be from minority group and had higher levels of depression and perceived stress compared with women with no trouble sleeping. This then leads to the question of whether improving sleep could be used as an option to buffer against the adverse effects of other risk factors for delayed time to pregnancy such as depression, anxiety or low socioeconomic status.There are also systematic biases in the way that sleep is self-reported within certain subgroups, such as people with depression or obesity, who feel tired and may suspect they sleep less than the norm, regardless of their actual measured sleep. Therefore, further studies where more objective measures of sleep quality through actigraphs or more rigorous standardized measures is recommended.

CONCLUSION: From a clinical perspective, treatment of disordered sleeping would not only enhance the quality of life, but also may represent a modifiable pathway for enhancing spontaneous fertility. This article has a fascinating first look at the association between sleep health in women and time to pregnancy, it is the first longitudinal studies to enhance our knowledge on this topic further. Given the growing trend in recognizing sleep disorders and sleep deprivation as an unmet public health problem, particularly among young women, clinicians and researchers alike should be encouraged to collect information on sleep habits and consider it as one of many important factors, in addition to a healthy diet and active lifestyle, in increasing wellness and potentially fertility in women.

REFERENCES:1. Wise L.A., Rothman K.J., Wesselink A.K., Mikkelsen E.M., Sorensen H.T., McKinnon C.J., Hatch E.E. 2018. Male sleep duration and fecundability in a North American preconception cohort study.Fertility and Sterility, 109 (3), pp. 453-459.


2. Gaskins A.J. Poor sleep and delayed time to pregnancy: a wake-up call for physicians and researchers? (2019).Fertility and Sterility, Available online from :https://doi.org/10.1016/j.fertnstert.2019.02.125

SOURCE: https://www.indianfertilitysociety.org/fertility-news-may-2019-volume-9/

Mohak laparoscopy and infertility center is India’s leading Best IVF center in Indore, mp. It is a ray of hope for childless couples. It proves to be a boon for couples who are normally unable to conceive. We provide all kinds of Infertility Treatments such as, Infertility treatment, IVF, ICSI treatment, IUI treatment, test tube baby treatment, and Laparoscopic surgery.

To book an appointment with the Doctors/ best IVF specialist at the best IVF center in MP, Indore, Call- 78980-47572 / 80852-77666 and online visit – https://www.mohakivf.com

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To More Post: Cochrane Review


Who should be treated by IVF in unexplained subfertility?

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“Should we be trying expectant management or IVF treatment?”

INTRODUCTION: The clinical indications for IVF, initially started from bilateral tubal blockage and now has extended to unexplained subfertility in which there is no identifiable cause or barrier to conception. There is little evidence from randomized controlled trials that IVF is effective in these couples.Which couples with unexplained subfertility can expect increased chances of ongoing pregnancy with IVF compared to expectant management ?

SUMMARY: Eekelen et al1 recently compared outcomes in couples with unexplained subfertility undergoing IVF (n = 40921) from registry data to couples with the same type of subfertility on expectant management. Those couples on expectant management (only intercourse) comprised a prospective nation wide Dutch cohort (n = 4875) and a retrospective regional cohort from Aberdeen, Scotland (n =975). They excluded couples who had tried for less than 1 year to conceive, cases of anovulation, tubal occlusion, mild or severe endometriosis or male subfertility. Matching of couples who received IVF and couples on expectant management based on their characteristics to control for confounding were done. They fitted a Cox proportional hazards model including patient characteristics, IVF treatment and their interactions to estimate the individualized chance of conception over 1 year, either following IVF or expectant management for all combinations of patient characteristics. The endpoint was conception leading to ongoing pregnancy, defined as a foetus reaching a gestational age of at least 12 weeks. The adjusted 1year chance of conception was 47.9% (95% CI: 45.0–50.9) after IVF and 26.1% (95% CI: 24.2–28.0) after expectant management. The absolute difference in the average adjusted 1 year chances of conception was 21.8% (95%CI: 18.3–25.3) in favour of IVF. The effectiveness of IVF was influenced by female age, duration of subfertility and previous pregnancy. IVF was effective in women under 40 years, but the 1 year chance of an IVF conception declined sharply in women over 34 years. In contrast, in woman over 40 years of age, IVF was less effective, with an absolute difference in chance compared to expectant management of 10% or lower. Regardless of female age, IVF was also less effective in couples with a short period of secondary subfertility (1 year) who had chances of natural conception of 30% or above.

CONCLUSION: For couples in which the woman is under 40 years of age, IVF is associated with higher chances of conception than expectant management in unexplained subfertile couples. IVF should be used selectively based on judgements on gain compared to continuing expectant management for a given couple.

REFERENCES: 1. R van Eekelen, N van Geloven, M van Wely, S Bhattacharya, F van der Veen, M J Eijkemans, D J McLernon. IVF for unexplained subfertility; whom should we treat?, Human Reproduction, dez072, https://doi.org/10.1093/humrep/dez072 Published 13 June 2019.

SOURCE: https://www.indianfertilitysociety.org/fertility-news-volume-10-july-2019/

Mohak laparoscopy and infertility center is one of the Best infertility hospital in indore, That provides the best IVF and test tube baby treatment in Indore. All treatments in our hospital are done at affordable price and cost by IVF experts only. One of the leading test tube baby center in Indore. visit our website and book an appointment https://www.mohakivf.com/ivf-center-in-indore.htm and call us this number 78980-47572 / 80852-77666

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To More Post: 10 Super-Foods that improves the sperm count and enhances fertility in males

How is Female Infertility treated using IVF?

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Female Infertility :

It has been observed in a study that about 10-15% of couples face problems with conception. There is a range of causes which affect fertility in women as well as men. Those couples who might be getting no result even after making attempts to have a baby may be keen on seeking IVF treatments. Located in the heart of India – Indore and established in the year of 2010, Mohak IVF is known for its excellence for making unfertile women successfully produce babies.

What is IVF technology?

Usually known by its short name IVF, In Vitro Fertilization is a new age assisted reproductive technology. This technology involves the extraction of eggs and retrieving a sperm sample, thereafter integration of an and sperm is done manually in a laboratory dish. The formed embryo(s) is then moved into the uterus.

How is Female Infertility treated using IVF?

IVF treatment procedure provides treatments for couples who can not have a biological child for more than a year (12 months). It helps anyone who has already gone through several options of effectless fertility treatment, or maybe in the case of the Fallopian tube congestion or may be low sperm quality, like initial treatment – both can be treated only by IVF.

Infertility is a problem for women who are unable to conceive after 12 months of pregnancy. It is quite common, about 15% of the pairs are facing problems in conceiving even after making attempts. Fertility problems can occur both in men as well as women and in some cases.

In Vitro Fertilization or in vitro fertilization, the option is in a comprehensive clinical process in which the eggs and sperm are obtained and then fertilized manually in the laboratory and then restored in the uterus. For the pairs who failed to conceive naturally, of course, the ultimate goal of the IVF process is the result of a healthy full pregnancy.

What Causes Female Infertility?

A woman may be infertile because of a number of reasons:

Cervical issues. Due to certain conditions that prevent sperm from going through the cervical canal.

Damage to your fallopian tubes. These structures take eggs from your ovaries, which produce eggs, in a uterus where the child develops. In the case of scars after pelvic inflammation, endometriosis and pelvic surgery, they may be damaged. Which can stop sperm from reaching the egg?

Hormonal problems. You can not be pregnant because your body does not pass through normal hormonal changes, which leads to the release of an egg from the ovary and to the thickening of the endometrium.

“Unexplained” infertility. This is something which affects about 20% of couples where the exact reasons behind pregnancy are never seen.

Female Infertility Treatments

Most women in their mid-30s or onwards wanting to have a baby might experience issues since their eggs start to fall as they are of lower quality. Ecological elements such as smoking cigarettes, excess weight, sexual background and also alcoholic beverages are usually very high-risk elements that have an effect on Female Infertility Treatments.

Unexplained infertility is an event that accounts for 15% of all non-regular participants which can be seen in all the important researches, without diagnosing the doctor due to the lack of experience of the children.

Get the solutions related to infertility with one of the best fertility doctor intend to provide the best infertility treatment in indore. She is one of the leading Infertility specialists in Indore.

More Post : What is the IVF Treatment Cost in India?

What is the IVF Treatment Cost in India?

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Age is an important factor:

With the increase in age, a woman’s ability to conceive a baby starts to decline. An important point to note is that when you use your own eggs, your rate of success is inversely proportional to your age. The younger you are more is the chances of success.

What Infertility Disorders Can Be Treated In India?

With the advancement in medical technology, we can see a lot of IVF centres across India which are capable of treating all types of Infertility disorders and help childless women gain a chance to conceive. Here are some of the disorders which are treated:

● Blocked or damaged Fallopian tubes.
● Ovulation-related disorders.
● Sperm-related disorders like low sperm count.
● Endometriosis.

Patients who are not willing a huge amount on treatment can sight India for world-class infertility treatment. The doctors are reputed and known for their personal attention to each patient. Apart from this, they are even known for migrating miles in order to make sure that the treatments they provided are successful.

How much does IVF treatment cost in India?

This is something every patient think before making up their mind for an IVF cycle and selecting an IVF centre. In this article, we have presented you with a basic structure of rates. The IVF Cost in India which includes all diagnostic and surgical procedures, test and treatments generally ranges between 1 to 1.25 Lakh per cycle. The cost of IVF cycles in India or across the world is gaining inclination because of modern diagnostic test, and treatment methods such as IUI, hysteroscopy, laparoscopy are taken in assistance to aid and facilitate infertility treatments cost. This is why, there is no upper limit to the amount of money one can spend in desire for a baby.

ART or Assisted Reproductive Technology is the bundle of all options of fertility treatment in which both sperm and eggs are managed. The ART process consists of surgical extraction of eggs from the ovaries of a woman. Thereafter, the extracted eggs are merged with the sperms. The next process is of restoration of these sperms and ovaries back to either a woman’s body or someone who can keep it on behalf of the original mother.

IVF cost – In vitro preparation is among the ART techniques of letting impregnation of the man, gametes of woman (sperm and an egg) occur outside the woman’s body system..

As seen through a recent Canadian and US survey, 40 out of 100 international couples are choosing India or putting India on the top for their IVF treatment whereas 50 of the couples were found to be looking for IVF with donor eggs. This is a pride moment for us to see that in India the success rate of IVF every year is attaining a new height.

Disclaimer: Please note that rates are subject to change as per hospitals, spread across the nation.

IVF treatment cost in Indore:

Talking about the IVF cost in Indore, it can vary in between a certain range depending upon whether it is including or excluding the cost of prescribed medicines and injections. Mohak IVF is one of the most renowned IVF centres in Indore, so it is suggested to call and speak to the executive to clear all your cost-related queries. The cost of IVF cycle is even not a fixed cost as many people have been found to spend more than Rs. 600,000 for the test tube baby treatment. There are numerous factors which influence the cost of IVF treatments fluctuations. The reasons behind the variations of costs may be the patient’s medical history, fertility issues or the need for several other treatments along with IVF. Mohak IVF is known for providing the most affordable IVF cost in Indore.

In case an IVF clinic offers an IVF cycle treatment for less than Rs.1,50,000, it is to be noted there may be some additional or hidden extra costs which will be billed later. Before going any further, the patient should always clear all the doubts related to the cost of IVF treatment like the cost of ultrasound, fertility drugs, blood work and monitoring etc. Raising

well-researched questions prior to the treatment can help you save from getting shocked because of surprisingly high medical bills and disputes with the clinic.

IVF clinics across India and their specialists have the expertise in performing satisfactory solutions for infertility. A patient need not to worry about getting treatment and conceiving as there are numerous reputed IVF centres across India which increases the chances of conceiving. This helps them see their dream of becoming a happy parent come true!

Mohak IVF is one of the best test tube baby center in indore is run by most popular and highly experienced IVF specialist and Fertility specialist. The centre have high success rate with focused on patient dedicated individual care. 

More Post : FET might be susceptible to an imperfect environment

    FET might be susceptible to an imperfect environment

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    “Can FET and fresh ET outcome in IVF cycles be affected by the open environment air pollution?”

    Introduction:

    IVF outcomes and human infertility can be a result of air pollution around us. It’s indicated in Choe et al [1] study that lower pregnancy rates in IVF cycles can be associated with ambient air pollution while controlled ovarian stimulation as well as the post-transfer period.Choe et al1 study indicated lower pregnancy rates in IVF cycles may be linked to ambient air pollution during controlled ovarian stimulation and the post-transfer period. Do the outcomes of frozen-thawed embryo transfer (FET) and fresh transfer are differentially affected byopen-air pollution?

    IVF outcomes and human infertility can be a result of air pollution around us. It’s indicated in Choe et al [1] study that lower pregnancy rates in IVF cycles can be associated with ambient air pollution while controlled ovarian stimulation as well as the post-transfer period.Choe et al1 study indicated lower pregnancy rates in IVF cycles may be linked to ambient air pollution during controlled ovarian stimulation and the post-transfer period. Do the outcomes of frozen-thawed embryo transfer (FET) and fresh transfer are differentially affected byopen-air pollution?

    Summary:

    Between January 2013 and December 2016, Wang et al [2] studied the adverse effects of air pollution in 11148 patients contributing to 16290 transfer cycles for IVF treatment cycles.The average age of the cohort was recorded to be 31.5 years. In order to estimate the daily ambient exposures to six main pollutants ( CO, O3, SO2, NO2, PM2.5, PM10) inverse distance weighing interpolation was used at an IVFclinical site, bestow to the data recorded at thefixed air quality monitoring stations inside the city. The exposure for every cycle was shown as the daily mean concentration of contaminants (pollutants) from oocyte retrieval to embryo transfer/cryopreservation. Analysis of exposures was performed on every quarter basis. A general equating estimate was used to study the relationship between pollutants and IVF results. The rate of clinical pregnancy and the rate of live birth of the course were recorded to be 55.1% and 47.1% respectively. 4013 patients among the included cycles, got 5299 FET cycles, bringing about 42.7% live birth per ET, while 9553 patients got 10991 new transfer cycles, bringing about 49.2% to live birth per ET. Raised SO2 and O3 levels wereessentially related with lower rates of live birth in FET cycles, while none of the pollutantswas significantly linked with bringing down of IVF results in new transfer cycles. The FET cycles in the most elevated quartile of SO2 and O3 exposure had essentially lower rates of live birth (balanced OR) in correlation with those in the least quartile. Models including all transfer cycles and collaboration terms (FET exposures) recommended that FET altogether improved the impacts of SO2 and O3 exposures on IVF results (P < 0.001). Representing every six contaminations, women in the top quartile of SO2 still had the least rates of live birth (OR 0.61, 95%CI 0.47–0.80).

    Conclusion:

    According to this study, embryos may be more vulnerable to a suboptimal environment which are undergoing FET in comparison to those which are undergoing fresh transfer. Elevated SO2 and O3 levels at the location of IVF were found to be significantly linked with lower rates of live birth following FET whereas it did not show any adverse effect on the contemporary new transfer results. In the locations and seasons which are heavily polluted, due to dynamic changes of the ambient air pollutant (specifically gaseous), fluctuation in FET outcomes can be seen.

    According to this study, embryos may be more vulnerable to a suboptimal environment which are undergoing FET in comparison to those which are undergoing fresh transfer. Elevated SO2 and O3 levels at the location of IVF were found to be significantly linked with lower rates of live birth following FET whereas it did not show any adverse effect on the contemporary new transfer results. In the locations and seasons which are heavily polluted, due to dynamic changes of the ambient air pollutant (specifically gaseous), fluctuation in FET outcomes can be seen.

    According to this study, embryos may be more vulnerable to a suboptimal environment which are undergoing FET in comparison to those which are undergoing fresh transfer. Elevated SO2 and O3 levels at the location of IVF were found to be significantly linked with lower rates of live birth following FET whereas it did not show any adverse effect on the contemporary new transfer results. In the locations and seasons which are heavily polluted, due to dynamic changes of the ambient air pollutant (specifically gaseous), fluctuation in FET outcomes can be seen.

    References:

    1.  Xin Li Wang, Jiali Cai, Lanlan Liu, Xiaoming Jiang, Ping Li, Aiguo Sha, Jianzhi Ren; Association between outdoor air pollution during in vitro culture and the outcomes of frozen-thawed embryo transfer, Human Reproduction, Volume 34, Issue 3, 1 March 2019, Pages441–451,https://doi.org/10.1093/humrep/dey3862.  Choe SA, Jun YB, Lee WS, Yoon TK, Kim SY. Association between ambient air pollution and pregnancy rate in women who underwent IVF. Hum Reprod. 2018 Jun1;33(6):1071-1078. doi: 10.1093/humrep/dey076. PubMed PMID: 29659826

    Mohak laparoscopy and infertility center is one of the best fertility centre in indore. We offer male & female infertility treatment, ICSI and assisted reproduction at affordable ivf cost in indore.

    More Post  : Diabetes and lower fertility rates are associated

    Diabetes and lower fertility rates are associated

    Mohak infertility center

    A variety of causes which includes being underweight, obesity, having diabetic complications, an autoimmune disease, and having PCOS, can lead to infertility.

    It is seen in a number of women with diabetes with the ability to conceive, especially if diabetes is all around controlled and healthy body weight is kept up. Diabetes is a disease that affects numerous individuals as well as their family members. The WHO predicted that more than one hundred and eighty million individuals all around the globe have diabetic issues. This figure will most likely to increase twofold by 2030. Type 1 diabetes, which is mostly known to affect youngsters, is developing alarmingly (at a speed of 3% every year) around the globe. About 70,000 children of fourteen years old are developing Type 1 diabetic issues every year. Type 2 diabetic problems are mostly found in a large number of youngsters and developing teens and the reason behind it is found to be the continuous rise of morbid obesity levels, and found in each developing and developed countries as well. All types of diabetes affect females from numerous points of view, the association between diabetes mellitus and infertility is clarified.

    Diabetes and female infertility

    Diabetes in women can lead to the conceiving process more difficult as well as it can show an adverse effect on foetus development. On one side, rise in the glucose levels declines the manufacturing of hormones, for example, progesterone, estrogens and testosterone which are important for the female fertility. This disease produces hormonal changes in the body and shows an adverse effect on menstrual cycles leading absent or delayed as well as premature menopause. The dysfunctions brought about by diabetes can decay in women influenced by obesity. In any case, by holding under strict control the blood glucose levels can help in maintaining good health condition and avoid these issues. It has been seen in medical studies that women having diabetes can also get pregnant and also produce a healthy offspring. But it has a condition which is to keep the blood sugar levels monitored before and after the period of pregnancy. In case of a lady willing to give birth to a baby, she should go for a diabetes level checkup to avoid any possibility of health complications during the pregnancy. The main motto of the checkup is to reach the blood glucose level meeting the levels of women left over by the diabetes condition.

    • Keep up a healthy diet by keeping control of over the food consumption and their amount as prescribed by endocrinologist’s medical guidelines.
    • Also, go for moderate exercises while you are pregnant.
    • It is recommended to keep everyday track of blood sugar levels.
    • Maintain a healthy weight while pregnant.

    Apart from these primary suggestions, it is also recommended to have proper medications and also regular consultations with your physician before and after the pregnancy is required to avoid any complications or issues. This is how a diabetic woman can safely conceive like other normal

    Here are certain conditions associated with reduced rates of fertility:

    • Polycystic ovary syndrome (PCOS)
    • Endometrial cancer (uterine cancer)
    • Premature menopause (premature ovarian failure)
    • Oligomenorrhea (irregular periods)
    • Secondary amenorrhea (absent periods)
    • Microvascular and cardiovascular complications

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    Most common causes of women infertility

    Mohak infertility center

    In different communities, infertility is still considered as a major healthcare problem. Due to high prevalence, this issue has doubled its importance. A major proportion of infertility is the result of environmental conditions and also have risk factors.

    What is female infertility?

    The inability to produce offsprings by a woman is known as female infertility. It is found that at least half of all those couples who consult for infertility have the female partner with the “problem”. In older days, it was a common myth that is is always a woman partner with the inability and they have to bear the brunt of the blame. Only about 5% of total couples who were seeking help with producing a baby considered to be because of male infertility.

    Listed below are some of the most common causes infertility found in women:

    1. Ovulation Disorders:

      To timely release, an egg from the ovary (ovulate), a very fine balance of a variety of hormones which includes estrogen, luteinizing hormone, progesterone, a follicle-stimulating hormone is needed. Due to the decrease in the levels of progesterone one can experience interference in the adhesion of the embryo with the uterine lining. With the result of this, the risk of miscarriage increases. A significant increase in the levels of estrogen is also related to infertility in women.

    • Ovarian Failure:

      It may be a result of the natural disorders (known as Turner’s Syndrome) or medical treatments for ovarian tumours. It can also occur as a result of chemotherapy and radiotherapy for the treatment of cancers and tumours in different parts of the body.

    • Endometriosis: When the uterine lining doesn’t form normally, this condition is referred to as Endometriosis. It blocks the fallopian tubes as it grows outside the reproductive tract. Almost 10% of infertile women are due to these blockages. Since there is adhesion between fallopian tubes, uterus and ovaries, the further movement of sperm gets blocked in advance cases of endometriosis. This, as a result, causes infertility. It is found from the studies that the eggs released by women having endometriosis have more chances of producing offsprings with genetic abnormalities in comparison to those not having the disease.
    • Uterine and Cervical Disorders: A woman can face problems in conception because of the Benign growths like the uterine wall which can interfere with its connection with the wall of the uterus.
    • Abnormalities in cervix shape:

      It makes the movement of sperm from the vagina to uterus through the vaginal tract to uterus really difficult because of the change in the texture of cervical mucus.

    • Age:

      A woman’s age is again an important factor which affects her fertility. With increasing age, the chances of conceiving get lowered in every woman. This is a fact

    that every woman is born with a finite number of eggs which gradually goes down with getting older. Apart from this, the quality of eggs also declines with increasing eggs. It is seen that the eggs become more inclined towards chromosomal abnormalities. The increasing age also affects other reproductive functions of the body such as hormone levels and ovulation as a result of this, risk of miscarriage increases.

    • Polycystic Ovaries:

      Because of having multiple cysts, such ovaries are found to be abnormally large in size. Women having Polycystic Ovaries Syndrome (PCOS) generally can’t ovulate.

    • Immunological Disorders:

      The sperm gets destroyed by the cervical mucus when sometimes, it contains antibodies which detect sperm as a toxic foreign invader. When the immune cells of a woman attack normal cells of the body because of autoimmune diseases, this is also responsible for ovarian problems.

    Since women infertility is a severe issue in most women, hence, the causes behind it are not limited. There are many other causes as well which can be a reason behind making a woman face difficulties while conceiving.

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